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is not so easy, because the region, the country, indeed the whole world are again part of an

even greater whole. That is why half of the work is actually done when we succeed in

defining an interesting section that we can model sufficiently to gain new insights from it.

For example, how does a heart attack happen? Often it happens in a sudden flash. But simi­

larly often a heart failure, the so-called cardiac insufficiency, announces itself, gets worse

and worse, and only then does the heart attack occur. Can we perhaps stop this process, can

modern medicine and bioinformatics help here?

5.1

Application Example: How Does Phosphorylation Cause

Heart Failure?

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5.1

5.1

5.2

5.1

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5.1

5.2

5  Systems Biology Helps to Discover Causes of Disease